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Department of Professional Pharmaceutical Sciences

Department of Professional Pharmaceutical Sciences

Division of Professional Pharmaceutical Sciences

Head: Prof.Dr.Gamze KÖKDİL

Department of Pharmacognosy

 The department do not independently issue certificates but contribute to the education and training of pharmacy. The division of Professional Pharmaceutical Sciences is composed of four departments :

 ·         Pharmacognosy

Department Head: Prof.Dr.Gamze KÖKDİL

 ·         Pharmacology

Department Head: Prof.Dr.Bahar TUNÇTAN

·         Pharmaceutical Chemistry

     Department Head: Prof.Dr. Öztekin ALGÜL

 ·         Pharmaceutical Toxicology

Department Head: Assistant Prof.Dilek BATTAL

 


Publications in International Scientific Journals(last two years)

2021
49. Cağli, A.; şenol, .; Temiz reşitoğlu, M.; Güden, D.; Sarı, A.; şahan fırat, S.; Tunçtan, B. Solubleepoxidehydrolaseinhibitortrifluoromethoxyphenyl3-(1-propionylpiperidin-4-yl)ureaprevents hyperalgesiathroughregulatingNLRC4inflammasome-relatedproinflammatoryandanti-inflammatorysignalingpathwaysinthelipopolysaccharide-inducedpainmousemodel. DRUG DEVELOPMENT RESEARCH, 2021, ---.
10.1002/ddr.21786
48. Güden, D.; Temiz reşitoğlu, M.; şenol , .; Kibar, D.; Yılmaz, .; Tunçtan, B.; Malik, K.; şahan fırat, S. mTOR inhibition as a possible pharmacological target in the management of systemic inflammatory response and associated neuroinflammation by lipopolysaccharide challenge in rats. CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, 2021, ---, ---.
47. Cagli, A.; Senol, S.; Temiz‐resitoglu, M.; Guden, D.; Sari, A.; Sahan‐firat, S.; Tunctan, B. Soluble epoxide hydrolase inhibitor TPPU prevents hyperalgesia through regulating NLRC4 inflammasome‐related pro‐inflammatory and anti‐inflammatory signaling pathways in the lipopolysaccharide‐induced pain mouse model. WILEY, 2021, 0-0.
http://dx.doi.org/10.1002/ddr.21786
46. Battal, D.; Sukuroglu, A.; Kocadal, K.; Unlusayin, I.; çok, I. Establishment of rapid, sensitive, and quantitative LC‐ESI‐MS/MS method coupled with liquid‐liquid extraction for measurement of urinary bisphenol A, 4‐t‐octylphenol, and 4‐nonylphenol. RAPID COMMUNICATION IN MASS SPECTROMETRY, 2021, 0, 0-0.
http://doi.org/10.1002/rcm.9084
45. Kocadal, K.; Alkaş, F.; Ulutaş, O.; Kurt, M.; Battal, D.; şardaş, S.; Etikan, .; Saygı, . Biomonitoring of Heavy Metal(oid)s in the Residents of Abandoned Mining District in Northern Cyprus. BIOLOGICAL TRACE ELEMENT RESEARCH, 2021, 1, 1-10.
https://doi.org/10.1007/s12011-020-02520-1
44. Güngör, .; Güzel, S.; ülger, M.; Kökdil, G. CHEMICAL COMPOSITION AND ANTIOXIDANT AND ANTIMICROBIAL ACTIVITIES OF TURKISH ENDEMIC Trigonella rhytidocarpa SEEDS. CHEMISTRY OF NATURAL COMPOUNDS, 2021, 57, 136-140.
http://dx.doi.org/10.1007/s10600-021-03298-x
43. Njoh, R.; Kocadal, K.; Alkaş, F.; Kurt, M.; Battal, D.; Saygı, . HEAVY METAL POLLUTION OF AGRICULTURAL SOILS AND VEGETABLES OF ABANDONED MINING DISTRICT IN NORTHERN CYPRUS . FRESENIUS ENVIRONMENTAL BULLETIN, 2021, 30, 1415-1423.
Publications_012.pdf
42. Kuzu, B.; Sari, O.; Erdem, S.; Algul, O.; Menges, N. Synthesis of Benzoxazole‐2‐carboxylate Derivatives: Electronic‐ and Position‐effect of Functional Groups and Computational Modeling of the Selectivity for Oxazole Ring. CHEMISTRYSELECT, 2021, 6, 2529-2538.
http://dx.doi.org/10.1002/slct.202100174
41. Senol, S.; Temiz-resitoglu, M.; Guden, D.; Sari, A.; Sahan-firat, S.; Tunctan, B. Suppression of TLR4/MyD88/TAK1/NF-κB/COX-2 Signaling Pathway in the Central Nervous System by Bexarotene, a Selective RXR Agonist, Prevents Hyperalgesia in the Lipopolysaccharide-Induced Pain Mouse Model. SPRINGER SCIENCE AND BUSINESS MEDIA LLC, 2021, 46, 624-637.
http://dx.doi.org/10.1007/s11064-020-03197-7
40. Ozay, Y.; Guzel, S.; Gokalp ozkorkmaz, E.; Kumas, M.; Uzun, C.; Yıldırım, Z.; Celik, A.; Camlıca, Y.; Yumrutas, O. Biochemical, Histopathologic, and Genotoxic Effects of Ethanol Extract of Salvia hypargeia (Fisch. & Mey.) on Incisional and Excisional Wounded Diabetic Rats. JOURNAL OF INVESTIGATIVE SURGERY, 2021, 34, 7-19.
http://dx.doi.org/10.1080/08941939.2019.1590483
2020
39. Tiftik, R.; Temiz reşitoğlu, M.; Güden, D.; Bayrak, G.; Yılmaz, .; ün, .; şahan fırat, S. Involvement of Rho-kinase/IκB-α/NF-κB activation in IL-1β induced inflammatory response and oxidative stress in human chondrocytes. CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, 2020, ---.
38. Biliktu, M.; Senol, S.; Temiz-resitoglu, M.; Guden, D.; Horat, M.; Sahan-firat, S.; Sevim, S.; Tunctan, B. Pharmacological inhibition of soluble epoxide hydrolase attenuates chronic experimental autoimmune encephalomyelitis by modulating inflammatory and anti-inflammatory pathways in an inflammasome-dependent and -independent manner. SPRINGER SCIENCE AND BUSINESS MEDIA LLC, 2020, 0-0.
http://dx.doi.org/10.1007/s10787-020-00691-w
37. Ersan, R.; Yuksel, A.; Ertan‐bolelli, T.; Dogen, A.; Burmaoglu, S.; Algul, O. One‐pot synthesis of novel benzimidazoles with a naphthalene moiety as antimicrobial agents and molecular docking studies. WILEY, 2020, 1-10.
http://dx.doi.org/10.1002/jccs.202000125
36. Akbaslar, D.; Giray, E.; Algul, O. Revisit to the synthesis of 1,2,3,4-tetrasubstituted pyrrole derivatives in lactic acid media as a green solvent and catalyst. SPRINGER SCIENCE AND BUSINESS MEDIA LLC, 2020, 2020, 1-10.
http://dx.doi.org/10.1007/s11030-020-10122-1
35. Algul, O.; Ersan, R.; Alagoz, M.; Duran, N.; Burmaoglu, S. An efficient synthesis of novel di-heterocyclic benzazole derivatives and evaluation of their antiproliferative activities. INFORMA UK LIMITED, 2020, 2020, 1-13.
http://dx.doi.org/10.1080/07391102.2020.1803966
34. Duran, G.; Küçük, M.; Algül, .; Terzi, M. Investigation of New Benzimidazole Derivative Compounds’ Effects on A549 Cell Line. FAPUNIFESP (SCIELO), 2020, 63, 1-8.
http://dx.doi.org/10.1590/1678-4324-2020190364
33. Uckun, Z.; Guzel, S.; Canacankatan, N.; Yalaza, C.; Kibar, D.; Coskun yilmaz, B. Potential protective effects of naringenin against vancomycin-induced nephrotoxicity via reduction on apoptotic and oxidative stress markers in rats. DRUG AND CHEMICAL TOXICOLOGY , 2020, 43, 104-111.
10.1080/01480545.2018.1512612
32. Tunctan, B. CYP-derived eicosanoids in inflammatory diseases. ELSEVIER BV, 2020, 148, 106424-106424.
http://dx.doi.org/10.1016/j.prostaglandins.2020.106424
31. özdemir, Z.; Utku, S.; Mathew, .; Carradori, S.; Orlando, G.; Di simone, S.; Alagoz, M.; Ozcelik, A.; Uysal, M. Synthesis and biological evaluation of new 3(2H)-pyridazinone derivatives as non-toxic anti-proliferative compounds against human colon carcinoma HCT116 cells. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY , 2020, 35, 1100-1109.
Publications_014.pdf
30. Aktaş, D.; Akinalp, G.; Sanli, F.; Yucel, M.; Gambacorta, N.; Nicolotti, O.; Karatas, O.; Algul, O.; Burmaoglu, S. Design, synthesis and biological evaluation of 3,5-diaryl isoxazole derivatives as potential anticancer agents. ELSEVIER BV, 2020, 30, 127427-127427.
http://dx.doi.org/10.1016/j.bmcl.2020.127427
29. Aktas, D.; Akınalp, G.; Sanlıalp, F.; Yücel, M.; Gambacortae, N.; Nicolottie, O.; Karatasc, O.; Algül, .; Burmaoğlu, S. . BIOORGANIC MEDICINAL CHEMISTRY LETTERS, 2020, 30, 127427-.
10.1016/j.bmcl.2020.127427
28. Burmaoglu, S.; Kazancioglu, E.; Kaya, R.; Kazancioglu, M.; Karaman, M.; Algul, O.; Gulcin, I. Synthesis of novel organohalogen chalcone derivatives and screening of their molecular docking study and some enzymes inhibition effects. ELSEVIER BV, 2020, 1208, 127868-127868.
http://dx.doi.org/10.1016/j.molstruc.2020.127868
27. Alas, M.; Alkas, B.; Aktaş şüküroğlu, A.; Genç altürk, R.; Battal, D. . JOURNAL OF MATERIALS SCIENCE, 2020, 55, 15074-15105.
26. Biliktu, M.; Senol, S.; Temiz-resitoglu, M.; Guden, D.; Horat, M.; Sahan-firat, S.; Sevim, S.; Tunctan, B. Pharmacological inhibition of soluble epoxide hydrolase attenuates chronic experimental autoimmune encephalomyelitis by modulating inflammatory and anti-inflammatory pathways in an inflammasome-dependent and -independent manner. INFLAMMOPHARMACOLOGY, 2020, 28, 1509-1524.
http://dx.doi.org/10.1007/s10787-020-00691-w
25. Güzel, S. Fatty acid, sterol, and tocol compositions; amino acid, mineral, total phenolic, and flavonoid contents; and antioxidant activity of seeds of two Vincetoxicum taxa. CHEMISTRY OF NATURAL COMPOUNDS, 2020, 56, 202-206.
http://https://link.springer.com/article/10.1007/s10600-020-02988-2
24. Kocadal, K.; Alkas, B.; Battal, D.; Saygı, . . HUMAN EXPERIMENTAL TOXICOLOGY, 2020, 39, 3-13.
23. Ayaz, F.; Ronak haj, E.; Kuzu, B.; Algül, . . IN VITRO CELLULAR DEVELOPMENTAL BIOLOGY-ANIMAL, 2020, 56, 34-41.
10.1007/s11626-019-00418-4
22. Ersan, R.; Yuksel, A.; Ertan‐bolelli, T.; Dogen, A.; Burmaoglu, S.; Algul, O. One‐pot synthesis of novel benzimidazoles with a naphthalene moiety as antimicrobial agents and molecular docking studies. J CHIN CHEM SOC., 2020, 68, 374-383.
http://dx.doi.org/10.1002/jccs.202000125
21. Oz, M.; Baskak, B.; Uckun, Z.; Artun, N.; Ozdemir, H.; Ozel, T.; Ozguven, H.; Suzen, H. Association between serotonin 2A receptor (HTR2A), serotonin transporter (SLC6A4) and brain-derived neurotrophic factor (BDNF) gene polymorphisms and citalopram/sertraline induced sexual dysfunction in MDD patients. PHARMACOGENOMICS J, 2020, 20, 443-450.
http://dx.doi.org/10.1038/s41397-019-0127-8
20. Guzel, S.; Uckun , Z.; Canacankatan, N.; Antmen, S.; Kibar, D.; Coskun yilmaz, B. Potential renoprotective effects of silymarin against vancomycin-induced nephrotoxicity in rats. DRUG CHEM TOXICOL, 2020, 43, 630-636.
http://dx.doi.org/10.1080/01480545.2019.1584208
19. Güzel, S.; ülger, M.; Kahraman, A. CHEMICAL COMPOSITION AND SOME BIOLOGICAL ACTIVITIES OF Salvia longipedicellata HEDGE MERICARPS. CHEMISTRY OF NATURAL COMPOUNDS, 2020, 56, 788-792.
10.1007/s10600-020-03153-5
18. şimşek, S.; Aktaş şüküroğlu, A.; Yetkin, D.; özbek, B.; Battal, D.; Genç altürk, R. . SCIENTIFIC REPORTS, 2020, 10, -.
17. çok, .; Toprak, .; Battal, D.; Aktaş şüküroğlu, A. . JOURNAL OF CLINICAL RESEARCH IN PEDIATRIC ENDOCRINOLOGY, 2020, 12, -.
16. Akgönüllü, S.; Battal, D.; Yalçın, M.; Yavuz alagöz, H.; Denizli, A. . MICROCHEMICAL JOURNAL, 2020, 153, -.
15. Ersan, R.; Alagöz, M.; Ertan bolelli, T.; Duran, N.; Burmaoğlu, S.; Algül, . . MOLECULAR DIVERSITY, 2020, , -.
https://doi.org/10.1007/s11030-020-10115-0
2019
14. Tunctan, B.; Senol, S.; Temiz-resitoglu, M.; Guden, D.; Sahan-firat, S.; Falck, J.; Malik, K. Eicosanoids derived from cytochrome P450 pathway of arachidonic acid and inflammatory shock. ELSEVIER BV, 2019, 145, 106377-106377.
http://dx.doi.org/10.1016/j.prostaglandins.2019.106377
13. Tunçtan, B.; şenol, .; Temiz reşitoğlu, M.; Güden, D.; şahan fırat, S.; Falck, J.; Malik, K. Eicosanoids derived from cytochrome P450 pathway of arachidonic acid and inflammatory shock. PROSTAGLANDINS OTHER LIPID MEDIATORS, 2019, 145, 106377-.
10.1016/j.prostaglandins.2019.106377
12. Ayaz, F.; Ronak haj, E.; Algül, . . MONATSHEFTE FUR CHEMIE - CHEMICAL MONTHLY, 2019, 150, 1137-1146.
10.1007/s00706-019-02398-3
11. Kocak, Z.; Temiz-resitoglu, M.; Guden, D.; Vezir, O.; Sucu, N.; Balcı, S.; Tamer-gumus, L.; Tunctan, B.; Malik, K. Modulation of oxidative–nitrosative stress and inflammatory response by rapamycin in target and distant organs in rats exposed to hindlimb ischemia–reperfusion: the role of mammalian target of rapamycin. CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, 2019, 97, 1193-1203.
http://dx.doi.org/10.1139/cjpp-2019-0394
10. özçelik, A.; özdemir, Z.; Sari, S.; Utku, S.; Uysal, M. A new series of pyridazinone derivatives as cholinesterases inhibitors: Synthesis, in vitro activity and molecular modeling studies. PHARMACOLOGICAL REPORTS, 2019, 71, 1253-1263.
http://dx.doi.org/10.1016/j.pharep.2019.07.006
9. Güzel, S.; özay, Y.; Kumaş, M.; Uzun, C.; özkorkmaz, E.; Yıldırım, Z.; ülger, M.; Güler, G.; çelik, A. Wound healing properties, antimicrobial and antioxidant activities of Salvia kronenburgii Rech. f. and Salvia euphratica Montbret, Aucher & Rech. f. var. euphratica on excision and incision wound models in diabetic rats. BIOMEDICINE & PHARMACOTHERAPY, 2019, 111, 1260-1276.
8. Ozay, Y.; Güzel, S.; Gökalp-özkorkmaz, E.; Yıldız, A.; Yıldırım, Z.; Erdoğdu, .; Darcan, S.; Pehlivanoğlu, B.; Kumaş, M. Effects of methanolic extract of Verbascum inulifolium Hub.-Mor. on incisional and excisional skin wounds in diabetic and non-diabetic rats. INDIAN JOURNAL OF EXPERIMENTAL BIOLOGY, 2019, 57, 157-167.
7. şahan fırat, S.; Temiz reşitoğlu, M.; Güden, D.; şenol, .; Sarı, A.; çil, M.; ünsal, D.; Korkmaz, B.; Tunçtan, B. NF-κB activation mediates LPS- or zymosan-induced hypotension and inflammation reversed by BAY61-3606, a selective Syk inhibitor, in rat models of septic and non-septic shock. CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, 2019, 46, 173-182.
10.1111/1440-1681.13045
6. Gülçin, .; Kaya, R.; Algül, .; Yilmaz, A.; Burmaoglu, S. . BIOORGANIC CHEMISTRY, 2019, 85, 191-197.
10.1016/j.bioorg.2018.12.035
5. Kuzu, B.; Ayaz, F.; Algül, . . JOURNAL OF HETEROCYCLIC CHEMISTRY, 2019, 56, 1946-1952.
10.1002/jhet.3573
4. özay, Y.; Güzel, S.; Yumrutaş, .; Pehlivanoğlu, B.; Erdoğdu, .; Yildirim, Z.; Türk, B.; Darcan, S. Wound Healing Effect of Kaempferol in Diabetic and Nondiabetic Rats. JOURNAL OF SURGICAL RESEARCH, 2019, 233, 284-296.
3. Ayaz, F.; Rusmeenee, K.; Qadar ahmed, I.; Ronak haj, E.; Algül, . . TURKISH JOURNAL OF CHEMISTRY, 2019, 43, 963-971.
10.3906/kim-1812-54
2. Burmaoğlu, S.; özcan, .; Balcıoğlu, S.; Gencel, M.; Noma, S.; Eşsiz gökhan, .; Ateş, B.; Algül, . . BIOORGANIC CHEMISTRY, 2019, 91, -.
10.1016/j.bioorg.2019.103149
1. Tunçtan, B.; şenol, .; Temiz reşitoğlu, M.; Güden, D.; şahan fırat, S.; Falck, J.; Ku, M. . PROSTAGLANDINS OTHER LIPID MEDIATORS, 2019, , -.